Antagonistic effect of sodium ascorbate on ethanol-induced changes in swimming of mice

Behav Brain Res. 1980 Aug;1(4):351-6. doi: 10.1016/0166-4328(80)90028-5.


Swimming behavior in the mouse was used to study the motor disturbances induced by alcohol, and the effects of vitamin C upon these disturbances were assessed. High doses of vitamin C (125 and 500 mg/kg) prevented any swimming impairment due to ethanol; however, lower doses of vitamin C (62.5 mg/kg) had no significant effect. When given 1 h before alcohol, the protective effect of vitamin C was reduced. The alcohol-induced intoxication lasted beyond alcohol's elimination from the blood, suggesting that the intoxication is maintained by a metabolite of ethanol or by an effect of ethanol, or a metabolite, on another metabolic system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetaldehyde / pharmacology
  • Animals
  • Ascorbic Acid / pharmacology*
  • Ethanol / antagonists & inhibitors*
  • Ethanol / blood
  • Male
  • Mice
  • Mice, Inbred Strains
  • Motor Activity / drug effects*
  • Swimming


  • Ethanol
  • Acetaldehyde
  • Ascorbic Acid