Polydipsia and abolition of angiotensin-induced drinking after transections of subfornical organ efferent projections in the rat

Brain Res. 1981 Nov 23;225(1):200-6. doi: 10.1016/0006-8993(81)90331-0.

Abstract

Rats with transections of subfornical organ (SFO) efferent projections failed to drink to intravenous angiotensin-II (AII) but responded to intracellular dehydration and water deprivation and suppressed drinking when food deprived. However, the transected rats were polydipsic and polyuric. Thus SFO efferent projections mediate AII-induced drinking and may be involved in the regulation of body fluid balance.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Angiotensin II / pharmacology*
  • Animals
  • Dose-Response Relationship, Drug
  • Drinking / drug effects*
  • Eating / drug effects
  • Efferent Pathways / physiology
  • Food Deprivation
  • Male
  • Neurosecretory Systems / physiology*
  • Rats
  • Rats, Inbred Strains
  • Subfornical Organ / physiology*
  • Water Deprivation
  • Water-Electrolyte Balance / drug effects

Substances

  • Angiotensin II