Abstract
In flavonoid-deficient Wistar-rats, the action of caffeine, harmine, hexobarbital, morphine and pentobarbital is enhanced. In contrast, the thiopental sleeping time is shortened. These observations may indicate impaired drug metabolism as a consequence of the flavonoid-deficiency state.
MeSH terms
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Animals
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Barbiturates / pharmacology
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Behavior, Animal / drug effects
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Caffeine / pharmacology
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Diet
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Flavonoids / deficiency*
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Harmine / pharmacology
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Male
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Morphine / pharmacology
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Pharmaceutical Preparations / metabolism*
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Rats
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Time Factors
Substances
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Barbiturates
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Flavonoids
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Pharmaceutical Preparations
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Caffeine
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Harmine
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Morphine