Endoscopic small intestinal biopsy

Gastrointest Endosc. 1981 Aug;27(3):162-7. doi: 10.1016/s0016-5107(81)73183-3.


Ninety-three patients with suspected small bowel disease were investigated by duodenal forceps biopsy via a fiberoptic endoscope. Three biopsies were usually taken from the distal end of the second part of the duodenum, orientated on a square of plastic mesh, and examined by stereomicroscopy and histology. There were no failures or complications. Using strict criteria, sections from 56% of the 299 biopsies were satisfactory for histological interpretation (compared with 76% of 346 biopsies taken via a hydraulic multiple biopsy capsule from a separate group of patients). At least one biopsy was satisfactory from 87% of the patients. A previous study having shown that biopsies from this site are comparable to those from the conventional site at the duodenojejunal junction, it is concluded that endoscopic duodenal biopsy is a valid alternative to conventional suction biopsy and, moreover, has a number of advantages.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biopsy / methods
  • Child
  • Child, Preschool
  • Duodenal Diseases / diagnosis
  • Duodenal Diseases / pathology*
  • Duodenoscopy
  • Duodenum / pathology*
  • Female
  • Fiber Optic Technology
  • Humans
  • Intestinal Mucosa / pathology
  • Male
  • Middle Aged