Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization

In Vitro. 1978 Nov;14(11):911-5. doi: 10.1007/BF02616120.


Nineteen human breast carcinoma cell lines have been established as continuous cultures during the past 6 years in our laboratory. This preliminary report is designed to list the lines by their designated code numbers (MDA-MB) and present a brief summary of their morphological, cytogenetic and biochemical characteristics. Sixteen of our lines were obtained from pleural effusions, two from brain metastases, and one from pericardial fluid. All lines have been shown to be distinct entities and are uncontaminated by HeLa cells or each other. A lq marker chromosome is present in all but one of the lines examined.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Animals
  • Brain Neoplasms
  • Breast Neoplasms*
  • Cell Line*
  • Epithelium
  • Female
  • Glucosephosphate Dehydrogenase / metabolism
  • Humans
  • Isoenzymes / metabolism
  • Mice
  • Mice, Nude
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Transplantation
  • Pericardial Effusion / cytology
  • Pleural Effusion / cytology


  • Isoenzymes
  • Glucosephosphate Dehydrogenase