Carboxymethyl-selenopyruvic acid as the product of the oxidative deamination of carboxymethyl-selenocysteine

Ital J Biochem. 1978 Mar-Apr;27(2):104-10.

Abstract

CMSeC labeled with 14C in the carboxymethyl moiety was incubated with snake venom L-aminoacid oxidase. As the product of the reaction only one ketoacid was detected, which retained all the radioactivity of the oxidized substrate. This clearly shows that no breakdown of the C-Se bond of CMSeC occurs during its oxidation, and confirms previously reported data indicating that the ketoacid arising from CMSeC is CMSeP.

MeSH terms

  • Amino Acid Oxidoreductases / metabolism
  • Carbocysteine / analogs & derivatives*
  • Carbocysteine / metabolism
  • Cysteine / analogs & derivatives*
  • Deamination
  • Oxidation-Reduction
  • Pyruvates / isolation & purification
  • Pyruvates / metabolism*
  • Selenium / metabolism

Substances

  • Pyruvates
  • Carbocysteine
  • Amino Acid Oxidoreductases
  • Selenium
  • Cysteine