Fosfomycin kinetics after intravenous and oral administration to human volunteers

Antimicrob Agents Chemother. 1981 Sep;20(3):393-7. doi: 10.1128/aac.20.3.393.

Abstract

The pharmacokinetics of fosfomycin, administered intravenously and orally at two different doses (20 and 40 mg/kg of body weight), was studied in seven volunteers. The elimination profile of this antibiotic, when administered intravenously, followed a two-compartment kinetic model, independent of dosage, giving an elimination half-life of 2.23 +/- 0.62 h and an average total volume of distribution at steady state of 0.34 liter/kg. Peak serum levels after rapid intravenous administration of 20 and 40 mg/kg were 132.1 +/- 31.8 and 259.3 +/- 32.5 micrograms/ml, respectively. Peak serum levels after oral administration were 7.1 +/- 1.6 and 9.4 +/- 3.6 micrograms/ml for the 20 and 40 mg/kg doses, respectively. During the first 24 h after administration, an average of 80% of the intravenous doses and less than 25% of the oral doses were recovered in the urine.

MeSH terms

  • Administration, Oral
  • Adult
  • Anti-Bacterial Agents / metabolism*
  • Biological Assay
  • Female
  • Fosfomycin / administration & dosage
  • Fosfomycin / metabolism*
  • Humans
  • Injections, Intravenous
  • Kinetics
  • Male
  • Middle Aged
  • Time Factors

Substances

  • Anti-Bacterial Agents
  • Fosfomycin