GDP binding to brown-adipose-tissue mitochondria of diabetic--obese (db/db) mice. Decreased binding in both the obese and pre-obese states

Biochem J. 1981 Mar 15;194(3):1019-22. doi: 10.1042/bj1941019.

Abstract

GDP binding to brown-adipose-tissue mitochondria from adult diabetic--obese (db/db) mice was significantly less than with lean siblings. Binding was also decreased in the mutant mice before obesity had begun to develop. Decreased GDP binding was found to result from a decrease in the number of binding sites.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue, Brown / metabolism*
  • Animals
  • Binding Sites
  • Diabetes Mellitus / metabolism*
  • Guanine Nucleotides / metabolism*
  • Guanosine Diphosphate / metabolism*
  • In Vitro Techniques
  • Kinetics
  • Mice
  • Mice, Obese
  • Mitochondria / metabolism*
  • Obesity*

Substances

  • Guanine Nucleotides
  • Guanosine Diphosphate