Abstract
GDP binding to brown-adipose-tissue mitochondria from adult diabetic--obese (db/db) mice was significantly less than with lean siblings. Binding was also decreased in the mutant mice before obesity had begun to develop. Decreased GDP binding was found to result from a decrease in the number of binding sites.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adipose Tissue, Brown / metabolism*
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Animals
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Binding Sites
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Diabetes Mellitus / metabolism*
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Guanine Nucleotides / metabolism*
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Guanosine Diphosphate / metabolism*
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In Vitro Techniques
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Kinetics
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Mice
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Mice, Obese
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Mitochondria / metabolism*
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Obesity*
Substances
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Guanine Nucleotides
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Guanosine Diphosphate