Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei

Int J Pept Protein Res. 1981 Aug;18(2):113-20. doi: 10.1111/j.1399-3011.1981.tb02047.x.


The complete amino acid sequence of sauvagine, a new active polypeptide from the skin of Phyllomedusa sauvagei, a frog of Central and South America, has been determined by automated liquid-phase procedure after specific removal of the N-terminal pyrrolidonecarboxylic acid, and specific cleavages at the single methionine and at the two arginine residues. The proposed sequence is: Pyr-Gly-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Ser-Leu-Glu-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile -Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Il e-NH2. Sauvagine possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands; it can be considered the prototype of a new family of amphibian peptides, in addition to the tachykinins, bradykinins, dermorphins, caerulein-like and bombesin-like peptides.

MeSH terms

  • Amino Acid Sequence
  • Amphibian Proteins
  • Animals
  • Anura
  • Chemical Phenomena
  • Chemistry
  • Peptide Fragments
  • Peptide Hormones
  • Peptides*
  • Skin / analysis*


  • Amphibian Proteins
  • Peptide Fragments
  • Peptide Hormones
  • Peptides
  • sauvagine