Mathematical prediction of drug distribution in vivo: studies with doxantrazole in rats

J Pharmacokinet Biopharm. 1978 Dec;6(6):521-37. doi: 10.1007/BF01062107.


A pharmacokinetic model incorporating 14 compartments and 29 transfer coefficients has been developed from experimental data obtained after intravenous administration of a single dose to describe the distribution of doxantrazole in the rate. The distribution calculated from the model agreed closely with that determined experimentally. In addition, the model was able to predict with considerable accuracy the distribution of doxantrazole after repeated dosing.

MeSH terms

  • Animals
  • Injections, Intravenous
  • Kidney / metabolism
  • Kinetics
  • Liver / metabolism
  • Models, Biological
  • Protein Binding
  • Rats
  • Tetrazoles / metabolism
  • Thioxanthenes / metabolism*
  • Time Factors
  • Tissue Distribution


  • Tetrazoles
  • Thioxanthenes