Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 44 (2), 151-78

A Cytogenetic Study of 1000 Spontaneous Abortions

A Cytogenetic Study of 1000 Spontaneous Abortions

T Hassold et al. Ann Hum Genet.


Cytogenetic analysis of 1000 spontaneous abortions showed 463 to have an abnormal chromosome constitution. The proportion of chromosome abnormalities varied with the gestational age of the abortus and the type of tissue cultured but was not significantly different among the five racial groups represented in the study population. It was suggested that differences in the rate of chromosome abnormalities among cytogenetic studies of spontaneous abortions were the result of methodological differences in sample selection rather than real biological variation among study populations. The only factor found to be unequivocally associated with the aetiology of chromosome abnormalities in spontaneous abortions was increasing maternal age in trisomies.

Similar articles

See all similar articles

Cited by 108 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources