Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis

Biochemistry. 1981 Nov 24;20(24):6912-20. doi: 10.1021/bi00527a026.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Binding Sites
  • Crystallization
  • Hydroxamic Acids*
  • Models, Molecular
  • Protein Binding
  • Protein Conformation
  • Structure-Activity Relationship
  • Thermolysin / metabolism*
  • X-Ray Diffraction
  • Zinc*

Substances

  • Hydroxamic Acids
  • Thermolysin
  • Zinc