Aspects of metabolism related to the occurrence of skin lesions in biotin-deficient chicks

Br Poult Sci. 1981 Sep;22(5):467-72. doi: 10.1080/00071688108447911.


1. Chicks were fed on biotin-deficient low- and high-protein diets supplemented with increasing concentrations of biotin. 2. Biotin deficiency decreased hepatic activity of pyruvate carboxylase [EC] but activity of acetyl-CoA carboxylase [EC] was comparatively unaffected. 3. Increasing dietary protein increased the severity of biotin deficiency as assessed by skin lesions and decreased plasma biotin concentrations. 4. The severity of the skin lesions over all the treatments was most closely related to plasma biotin concentration.

MeSH terms

  • Animals
  • Biotin / deficiency*
  • Chickens / metabolism*
  • Dietary Proteins / metabolism
  • Female
  • Liver / metabolism
  • Poultry
  • Poultry Diseases / metabolism*
  • Pyruvate Carboxylase / metabolism
  • Skin Diseases / metabolism
  • Skin Diseases / veterinary*


  • Dietary Proteins
  • Biotin
  • Pyruvate Carboxylase