Candiplanecin, a new antibiotic from Ampullariella regularis subsp. mannitophila subsp. nov. I. Taxonomy of producing organism and fermentation

J Antibiot (Tokyo). 1981 Aug;34(8):929-33. doi: 10.7164/antibiotics.34.929.

Abstract

A soil isolate of actinomycete, strain No. 43871 produced a new antifungal antibiotic, candiplanecin. Pale brownish to yellow orange color of colonies on agar media, the formation of bottle-shaped, cylindrical sporangia bearing motile spores and the presence of meso-DAP and glycine in the cell wall ascribed this strain to genus Ampullariella. From its morphological characteristics together with the cultural and physiological features, this strain was determined to be a new subspecies of Ampullariella regularis and designated as Ampullariella regularis subsp. mannitophila subsp. nov. (FERM-P No. 5646). Production of candiplanecin was carried out by conventional submerged culture, in which 2 micrograms/ml as the highest antibiotic titer was obtained.

MeSH terms

  • Actinomycetales / classification*
  • Actinomycetales / physiology
  • Anti-Bacterial Agents / biosynthesis*
  • Fermentation

Substances

  • Anti-Bacterial Agents
  • candiplanecin