Antitumor agents. 49 tricin, kaempferol-3-O-beta-D-glucopyranoside and (+)-nortrachelogenin, antileukemic principles from Wikstroemia indica

J Nat Prod. Sep-Oct 1981;44(5):530-5. doi: 10.1021/np50017a003.

Abstract

Bioassay-directed isolation of the antitumor extract of Wikstroemia indica (Thymelaeaceae) has led to the characterization of tricin, kaempferol-3-O-beta-D-glucopyranoside, and (+)-nortrachelogenin as the major antileukemic constituents. In addition, daphnoretin was identified as the potent antitumor principle in vivo against the Ehrlich ascites carcinoma growth in mice.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic*
  • Carcinoma, Ehrlich Tumor / drug therapy
  • Diterpenes / pharmacology*
  • Flavonoids / pharmacology*
  • Furans*
  • Guaiacol / analogs & derivatives*
  • Guaiacol / pharmacology
  • Kaempferols*
  • Lignans*
  • Male
  • Mice

Substances

  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Flavonoids
  • Furans
  • Kaempferols
  • Lignans
  • nortrachelogenin
  • Guaiacol
  • astragalin
  • tricin