Vitamin C, titrating to bowel tolerance, anascorbemia, and acute induced scurvy

Med Hypotheses. 1981 Nov;7(11):1359-76. doi: 10.1016/0306-9877(81)90126-2.


A method of utilizing vitamin C in amounts just short of the doses which produce diarrhea is described (TITRATING TO BOWEL TOLERANCE). The amount of oral ascorbic acid tolerated by a patient without producing diarrhea increase somewhat proportionately to the stress or toxicity of his disease. Bowel tolerance doses of ascorbic acid ameliorate the acute symptoms of many diseases. Lesser doses often have little effect on acute symptoms but assist the body in handling the stress of disease and may reduce the morbidity of the disease. However, if doses of ascorbate are not provided to satisfy this potential draw on the nutrient, first local tissues involved in the disease, then the blood, and then the body in general becomes deplete of ascorbate (ANASCORBEMIA and ACUTE INDUCED SCURVY). The patient is thereby put at risk for complications of metabolic processes known to be dependent upon ascorbate.

MeSH terms

  • Administration, Oral
  • Adult
  • Ascorbic Acid / administration & dosage*
  • Ascorbic Acid / blood
  • Ascorbic Acid / therapeutic use
  • Diarrhea / chemically induced*
  • Drug Tolerance
  • Humans
  • Intestine, Large / drug effects*
  • Scurvy / drug therapy
  • Stress, Physiological
  • Surgical Procedures, Operative


  • Ascorbic Acid