Evidence for heterosis in the HLA system

Am J Hum Genet. 1981 Nov;33(6):894-9.


The number of persons with homozygous HLA haplotypes in several groups of South American Indians was 39% less than that expected assuming unmodified equilibrium. In a subpopulation of 122 persons whose parents' HLA constitutions were known, there were 56% fewer homozygous persons than expected. This deficit was widely distributed in different haplotypes and different tribal groups.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Brazil
  • Female
  • HLA Antigens / genetics*
  • Haploidy
  • Homozygote
  • Humans
  • Hybrid Vigor*
  • Hybridization, Genetic*
  • Indians, South American*
  • Male
  • Polymorphism, Genetic


  • HLA Antigens