Effects of catalase, peroxidase, superoxide dismutase and 10 scavengers of oxygen radicals in carrageenin edema and in adjuvant arthritis of rats

Experientia. 1981 Dec 15;37(12):1313-4. doi: 10.1007/BF01948381.

Abstract

Catalase, peroxidase and superoxide dismutase were found to inhibit significantly carrageenin edema and the primary phase of adjuvant arthritis in rats after i.v. injection. Heat-inactivated enzymes were as effective as the native enzymes. None of 10 scavengers of oxygen radicals inhibited the adjuvant arthritis at any time. Accordingly, no evidence for a participation of oxygen radicals in the secondary arthritis phase could be found, whereas a role of oxygen radicals in the primary arthritis phase and in carrageenin edema cannot be ruled out.

MeSH terms

  • Animals
  • Arthritis / prevention & control*
  • Arthritis, Experimental / prevention & control*
  • Carrageenan
  • Catalase / therapeutic use*
  • Edema / chemically induced
  • Edema / prevention & control*
  • Female
  • Free Radicals
  • Horseradish Peroxidase / therapeutic use*
  • Oxygen
  • Peroxidases / therapeutic use*
  • Rats
  • Rats, Inbred Strains
  • Superoxide Dismutase / therapeutic use*

Substances

  • Free Radicals
  • Carrageenan
  • Horseradish Peroxidase
  • Peroxidases
  • Catalase
  • Superoxide Dismutase
  • Oxygen