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, 4 (11), 879-85

A Pharmacokinetic Analysis Program (Multi) for Microcomputer

A Pharmacokinetic Analysis Program (Multi) for Microcomputer

K Yamaoka et al. J Pharmacobiodyn.


A nonlinear least squares program (MULTI) for microcomputers was developed. The program is written in BASIC programming language. Four algorithms, (1) Gauss-Newton method, (2) damping Gauss-Newton method, (3) modified Marquardt method and (4) simplex method, can be used for nonlinear curve fitting in MULTI. Up to five pharmacokinetic equations, which are voluntarily defined by the user, are simultaneously fitted to observed time courses. The executions of MULTI are demonstrated for time courses of ampicillin and oxacillin in man.

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