Lower gastrointestinal side effects of nonsteroidal antiinflammatory drugs

J Rheumatol. Nov-Dec 1981;8(6):952-4.


It has been well accepted that the nonsteroidal antiinflammatory drugs (NSAID) can cause upper gastrointestinal (GI) blood loss and reactivation of peptic ulcer disease. This report describes 3 patients in whom the ingestion of a NSAID was temporally associated with serious lower GI disease, including bleeding in 2 patients. These cases suggest an association between NSAID and activation of serious lower GI disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Anti-Inflammatory Agents / adverse effects*
  • Female
  • Gastrointestinal Diseases / chemically induced*
  • Humans
  • Male
  • Middle Aged


  • Anti-Inflammatory Agents