Toxicity of methotrexate and metoprine in a dihydrofolate reductase gene-amplified mouse cell line

Mol Pharmacol. 1981 Nov;20(3):637-43.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Line
  • Clone Cells
  • Deoxyuridine / metabolism
  • Folic Acid Antagonists / toxicity*
  • Kinetics
  • Methotrexate / metabolism
  • Methotrexate / toxicity*
  • Phosphorus Radioisotopes
  • Pyrimethamine / analogs & derivatives*
  • Pyrimethamine / toxicity
  • Tetrahydrofolate Dehydrogenase / genetics
  • Tetrahydrofolate Dehydrogenase / metabolism*

Substances

  • Folic Acid Antagonists
  • Phosphorus Radioisotopes
  • metoprine
  • Tetrahydrofolate Dehydrogenase
  • Deoxyuridine
  • Methotrexate
  • Pyrimethamine