Thiobarbituric acid reactive material in uremic blood

Nephron. 1981;29(1-2):40-3. doi: 10.1159/000182236.


The thiobarbituric acid (TBA) assay was applied to uremic blood. Significant TBA-reactive material was found in patients with chronic renal failure compared to normal controls. The presence of TBA-reactive material correlated with the degree of renal failure, and was removed by hemodialysis. The reactive material is not 2-deoxyribose or sialic acid. In addition, the presence of TBA-reactive material in uremic blood is not abolished by prior aspirin ingestion, suggesting it is not related to active prostaglandin synthesis. The possible origin of the TBA-reactive material in uremic blood is discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Creatinine / blood
  • Deoxyribose / metabolism
  • Humans
  • Kidney Diseases / blood
  • Random Allocation
  • Renal Dialysis
  • Sialic Acids / metabolism
  • Thiobarbiturates* / metabolism
  • Uremia / blood*


  • Sialic Acids
  • Thiobarbiturates
  • Deoxyribose
  • Creatinine
  • thiobarbituric acid