Determination of radiochemical purity and pharmacokinetic parameters of 99mTc-sulphur colloid and 99mTc-tin colloid

Nuklearmedizin. 1981 Dec;20(6):279-82.

Abstract

Labelling yield and radiochemical purity, higher than 95%, of 99mTc-colloid preparations were determined by using the paper chromatography method. Less than 3% of labelled citric acid, added to the preparation as a buffer solution, has been found in 99mTc-sulphur colloid. High radiochemical purity and optimum size of colloid particles has also been proved by biodistribution studies on experimental animals. The analysis performed has shown that more than 50% of 99mTc-colloid preparations excreted by urine is 99mTcO-, the remaining past 50% being protein bound 99mTc. Biological half-time of excretion of the fast phase is the same for both preparations, i.e. 10 min, while for the slow component it is 120 min in 99mTc-S-colloid and 160 min in 99mTc-Sn colloid.

MeSH terms

  • Animals
  • Half-Life
  • Kinetics
  • Rats
  • Reagent Kits, Diagnostic / standards*
  • Sulfur / metabolism
  • Sulfur / standards*
  • Technetium / metabolism
  • Technetium / standards*
  • Technetium Compounds*
  • Technetium Tc 99m Sulfur Colloid
  • Tin / metabolism
  • Tin / standards*
  • Tin Compounds*
  • Tissue Distribution
  • Yugoslavia

Substances

  • Reagent Kits, Diagnostic
  • Technetium Compounds
  • Tin Compounds
  • technetium Tc 99m tin colloid
  • Technetium Tc 99m Sulfur Colloid
  • Sulfur
  • Technetium
  • Tin