Effect of propranolol on the airway response to prostaglandin E2 in normal man

Br J Clin Pharmacol. 1981 Nov;12(5):731-5. doi: 10.1111/j.1365-2125.1981.tb01297.x.


1 The airway response to inhaled prostaglandin E2 (PGE2) and the effect of oral propranolol on this response was studied in eight normal subjects in a double-blind randomised trial. The airway response was measured as specific airway conductance (sGaw). 2 Inhalation of PGE2 caused retrosternal soreness, coughing and an awareness of mucus production. Despite this, PGE2 caused bronchodilatation and reproducible dose-response curves were obtained, with a maximum increase in sGaw of 53%. 3 Inhalation of the diluent of PGE2, an ethanol/saline mixture, did not cause irritation nor did it alter sGaw. 4 Prior administration of propranolol 80 mg did not alter baseline sGAW, nor the response to PGE2, indicating that the action of PGE2 in vivo is unaffected by bronchial beta-adrenoceptor blockade. 5 This technique should be of value in studying bronchodilator prostaglandins and their interaction with other drugs.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Airway Resistance / drug effects*
  • Bronchodilator Agents / pharmacology
  • Dose-Response Relationship, Drug
  • Humans
  • Male
  • Propranolol / pharmacology*
  • Prostaglandins E / pharmacology*


  • Bronchodilator Agents
  • Prostaglandins E
  • Propranolol