Hypoglycemic activity of polypeptide-p from a plant source

J Nat Prod. 1981 Nov-Dec;44(6):648-55. doi: 10.1021/np50018a002.

Abstract

A hypoglycemic peptide, Polypeptide-p, has been isolated from fruit, seeds, and tissue of Momordica charantia Linn (bitter gourd). Amino acid analysis indicates a minimum molecular weight of approximately 11,000 (166 residues). Polypeptide-p is a very effective hypoglycemic agent when administered subcutaneously to gerbils, langurs, and humans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Amino Acids / analysis
  • Animals
  • Cercopithecidae
  • Crystallization
  • Diabetes Mellitus / drug therapy
  • Electrophoresis, Disc
  • Female
  • Gerbillinae
  • Humans
  • Hypoglycemic Agents / isolation & purification*
  • Hypoglycemic Agents / therapeutic use
  • Male
  • Middle Aged
  • N-Glycosyl Hydrolases*
  • Plant Proteins / isolation & purification*
  • Plants, Medicinal / chemistry*
  • Ribosome Inactivating Proteins, Type 2

Substances

  • Amino Acids
  • Hypoglycemic Agents
  • Plant Proteins
  • Ribosome Inactivating Proteins, Type 2
  • N-Glycosyl Hydrolases