Abstract
A hypoglycemic peptide, Polypeptide-p, has been isolated from fruit, seeds, and tissue of Momordica charantia Linn (bitter gourd). Amino acid analysis indicates a minimum molecular weight of approximately 11,000 (166 residues). Polypeptide-p is a very effective hypoglycemic agent when administered subcutaneously to gerbils, langurs, and humans.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Amino Acids / analysis
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Animals
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Cercopithecidae
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Crystallization
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Diabetes Mellitus / drug therapy
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Electrophoresis, Disc
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Female
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Gerbillinae
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Humans
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Hypoglycemic Agents / isolation & purification*
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Hypoglycemic Agents / therapeutic use
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Male
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Middle Aged
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N-Glycosyl Hydrolases*
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Plant Proteins / isolation & purification*
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Plants, Medicinal / chemistry*
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Ribosome Inactivating Proteins, Type 2
Substances
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Amino Acids
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Hypoglycemic Agents
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Plant Proteins
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Ribosome Inactivating Proteins, Type 2
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N-Glycosyl Hydrolases