Suppression of the humoral immune response to inactivated Newcastle disease virus by Mycoplasma meleagridis in the Turkey

Avian Dis. 1981 Oct-Dec;25(4):894-9.


Groups of Mycoplasma meleagridis-free and -infected turkeys were vaccinated against Newcastle disease virus (NDV) at 5 and 8 weeks of age. The two groups did not differ significantly in antibody response to NDV as measured by the hemagglutination-inhibition test when a live vaccine (TCND) was used, but the two groups differed significantly when an inactivated vaccine was used; titers were higher in the mycoplasma-free group in both primary and secondary responses. The difference between responses of the mycoplasma-free and -infected groups to inactivated and live NDV was explained by a current hypothesis about the ontogeny of B-cell differentiation in the bursa of Fabricius and by its interference by M. meleagridis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Viral / biosynthesis*
  • Bursa of Fabricius / immunology
  • Bursa of Fabricius / microbiology
  • Hemagglutination Inhibition Tests / veterinary
  • Mycoplasma Infections / immunology
  • Mycoplasma Infections / microbiology
  • Mycoplasma Infections / veterinary*
  • Newcastle disease virus / immunology*
  • Poultry Diseases / immunology*
  • Poultry Diseases / microbiology
  • Turkeys* / immunology*
  • Vaccines, Attenuated / immunology
  • Viral Vaccines / immunology*


  • Antibodies, Viral
  • Vaccines, Attenuated
  • Viral Vaccines