Investigation of the tumorigenic response to benzo(a)pyrene in aqueous caffeine solution applied orally to Sprague-Dawley rats

J Cancer Res Clin Oncol. 1981;102(2):153-7. doi: 10.1007/BF00410666.


In a lifetime experiment benzo(a)pyrene (B(a)P) was administered to Sprague-Dawley rats either as an admixture to the diet or by gavage in an aqueous 1.5% caffeine solution. Dissolved benzo(a)pyrene induced more tumors of the forestomach than undissolved benzo(a)pyrene. The 1.5% caffeine solution (annual dose 27 g/kg) did not exert any carcinogenic activity under the conditions of this bioassay.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Benzopyrenes / administration & dosage*
  • Benzopyrenes / toxicity
  • Caffeine / administration & dosage*
  • Drug Synergism
  • Female
  • Male
  • Neoplasms, Experimental / chemically induced*
  • Rats
  • Rats, Inbred Strains
  • Solubility
  • Solutions


  • Benzopyrenes
  • Solutions
  • Caffeine