Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease

J Clin Endocrinol Metab. 1980 Jan;50(1):113-6. doi: 10.1210/jcem-50-1-113.


We evaluated basal plasma total immunoreactive insulin (insulin), androstenedione, and testosterone in 14 obese women: 8 with polycystic ovarian disease (PCOD) and 6 obese controls. All 3 hormones were significantly elevated (P less than 0.02 to P less than 0.001) in PCOD patients. A significant correlation among basal levels of plasma insulin, androstenedione, and testosterone was demonstrated. The PCOD group had significantly higher levels of glucose at 1, 2, and 3 h, with similar significant increases in plasma insulin levels at 0, 2, and 3 h. A significant correlation was found between plasma insulin response areas and plasma testosterone (P less than 0.001) in the control and PCOD patients. These studies demonstrate that hyperandrogenism correlates with hyperinsulinism.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Androstenedione / blood*
  • Female
  • Humans
  • Insulin / blood*
  • Obesity / blood
  • Obesity / complications
  • Polycystic Ovary Syndrome / blood*
  • Polycystic Ovary Syndrome / complications
  • Testosterone / blood*


  • Insulin
  • Testosterone
  • Androstenedione