Developmental changes in glucose transport of guinea pig erythrocytes

J Clin Invest. 1980 Jan;65(1):1-4. doi: 10.1172/JCI109638.


The developmental changes in the capacity for D-glucose transport of guinea pig erythrocyte membranes were compared to alterations in the electrophoretic pattern of erythrocyte membrane components. Guinea pig erythrocytes lose their D-glucose carrier functions during development. Good correlation was observed between the loss of glucose uptake and apparent decrease of the zone 4.5 of Coomassie Blue-stained membrane proteins on electrophoresis. Reconstitution of membrane preparations in liposomes resulted in a parallel change in the D-glucose uptake and D-glucose penetration of intact erythrocytes. This suggests that the decrease of D-glucose transport capacity during development is caused by the loss of one or more protein components from the erythrocyte membranes.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Animals
  • Biological Transport, Active
  • Blood Glucose / metabolism*
  • Carrier Proteins / blood
  • Carrier Proteins / isolation & purification
  • Electrophoresis, Polyacrylamide Gel
  • Erythrocyte Membrane / metabolism*
  • Erythrocytes / metabolism*
  • Guinea Pigs
  • Liposomes
  • Membrane Proteins / blood


  • Blood Glucose
  • Carrier Proteins
  • Liposomes
  • Membrane Proteins