Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine

Brain Res. 1980 Jan 6;181(1):151-60. doi: 10.1016/0006-8993(80)91265-2.


Repeated administration of high doses of methamphetamine produced long-term decreases in dopamine (DA) levels and in the number of DA uptake sites in the rat striatum. These two effects were dose-related and did not appear to be due to the continued presence of drug in striatal tissue. Long-lasting depletions induced by methamphetamine were selective for striatal DA neurons since norepinephrine (NE) levels in all of the rat brain regions examined were not changed on a long-term basis by methamphetamine treatments. Supersensitivity of DA receptors did not accompany the loss of striatal DA and its uptake sites.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Caudate Nucleus / metabolism
  • Corpus Striatum / drug effects
  • Corpus Striatum / metabolism*
  • Dopamine / metabolism*
  • Dose-Response Relationship, Drug
  • Kinetics
  • Male
  • Methamphetamine / pharmacology*
  • Norepinephrine / metabolism
  • Rats
  • Receptors, Dopamine / drug effects
  • Receptors, Dopamine / metabolism*


  • Receptors, Dopamine
  • Methamphetamine
  • Dopamine
  • Norepinephrine