Urinary tract infections in children: effect of short course antibiotic therapy on recurrence rate in children with previous infections

Clin Pediatr (Phila). 1980 Feb;19(2):121-4. doi: 10.1177/000992288001900206.


Eighty-five girls, ages 3-16, with a past history of recurrent urinary tract infections were treated for 10 days with either trimethoprim/sulfamethoxazole, ampicillin or cephalexin. Patients with normal roentgenograms as well as those with reflux and cortical scarring were included. In the 12 weeks following completion of treatment, a significantly lower recurrence rate was noted in children who received trimethoprim/sulfamethoxazole. There was no difference in the recurrence rate whether or not radiographic abnormalities were present. No serious side effects were noted with any drug regimen.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Ampicillin / therapeutic use*
  • Cephalexin / therapeutic use*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Recurrence
  • Sulfamethoxazole / administration & dosage
  • Sulfamethoxazole / therapeutic use*
  • Trimethoprim / administration & dosage
  • Trimethoprim / therapeutic use*
  • Urinary Tract Infections / drug therapy*
  • Urinary Tract Infections / microbiology


  • Ampicillin
  • Trimethoprim
  • Sulfamethoxazole
  • Cephalexin