Benign lipoblastomatosis: ultrastructure and histogenesis

Cancer. 1980 Feb;45(3):511-5. doi: 10.1002/1097-0142(19800201)45:3<511::aid-cncr2820450316>;2-a.


Ultrastructural study of a case of benign lipoblastomatosis revealed a cellular spectrum which included undifferentiated mesenchymal cells, stellate myxoid cells, fibroblasts, lipoblasts, lipocytes and many intermediate forms. The uni- and multivacuolated fat cells contained membrane and non-membrane bound cytoplasmic vacuoles, predominatly of saturated lipid. Their cytoplasm also contained simple-structured mitochondria devoid of intramatrical or crystalloid bodies. The fine structure of the cellular components of lipoblastomatosis supports the concept that this is a neoplasm related to fetal white fat rather than to brown fat.

Publication types

  • Case Reports

MeSH terms

  • Adipose Tissue / ultrastructure
  • Child, Preschool
  • Fetus / ultrastructure
  • Humans
  • Lipomatosis / etiology
  • Lipomatosis / ultrastructure*
  • Male
  • Microscopy, Electron
  • Pharyngeal Neoplasms / etiology
  • Pharyngeal Neoplasms / ultrastructure*
  • Vacuoles / ultrastructure