Serum concentrations of C3 and C4 of the complement system in patients with chronic obstructive pulmonary disease

J Lab Clin Med. 1980 Feb;95(2):266-71.


In a search for host factors for the complex multifactoral disease, chronic obstructive pulmonary disease, we compared some major components of the complement system in 111 subjects with forced expiratory volumes in 1 sec less than 70% of predicted (index subjects) to those in 111 subjects matched as pairs for age, sex, smoking, and occupation having forced expiratory volumes in 1 sec more than 85% of predicted normal. Significantly lower blood levels of C3 and C4 were found in the index subjects (p less than 0.001). Among the index subjects there was a significant correlation between chronic cough and expectoration and low C3 and C4. There was not a significant correlation between low values and the frequency and severity of past respiratory infections. Levels of serum B globulin fraction, in which C3 and C4 migrate, were not different between the index and control subjects.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Complement C3 / analysis*
  • Complement C4 / analysis*
  • Humans
  • Lung Diseases, Obstructive / blood
  • Lung Diseases, Obstructive / immunology*
  • Middle Aged


  • Complement C3
  • Complement C4