Problems associated with the management of pregnancies in patients with systemic lupus erythematosus

J Rheumatol. Jan-Feb 1980;7(1):37-49.

Abstract

Eighty-three percent of 24 pregnancies in patients with systemic lupus erythematosus studied retrospectively terminated in normal children. Fifty-four percent of patients had clinical and serological disease exacerbations during pregnancy or in the post-partum period, as contrasted with 4% in the 6 months prior to pregnancy. The presence of significant renal disease and SLE activity in the 6 months prior to pregnancy correlated with exacerbations. A distinction between pre-eclamptic toxemia and lupus exacerbation had to be made in 25% of our patients. There were 2 maternal deaths associated with uncontrolled lupus activity. No potentially viable infants died for reasons directly related to lupus activity.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abortion, Therapeutic
  • Adult
  • Antibodies / analysis
  • DNA / immunology
  • Female
  • Fetal Viability
  • Humans
  • Infant, Newborn
  • Lupus Erythematosus, Systemic / drug therapy
  • Lupus Erythematosus, Systemic / immunology
  • Lupus Erythematosus, Systemic / therapy*
  • Male
  • Maternal Mortality
  • Prednisolone / therapeutic use
  • Pregnancy
  • Pregnancy Complications / drug therapy
  • Pregnancy Complications / immunology
  • Pregnancy Complications / therapy*

Substances

  • Antibodies
  • DNA
  • Prednisolone