Cellular immune responsiveness of uveitis patients to retinal S-antigen

Am J Ophthalmol. 1980 Feb;89(2):173-9. doi: 10.1016/0002-9394(80)90108-7.


S-antigen, an organ-specific substance isolated from the retinal photoreceptor region, was shown to be a potent agent for the induction of experimental autoimmune uveitis. S-antigen and other ocular antigens were tested for their ability to induce blast transformation of lymphocytes from patients with a variety of ocular inflammatory diseases. Lymphocytes from 22% of patients tested manifested a positive memory response to the S-antigen prepared from bovine eyes. Responses to human S-antigen paralleled those found with the bovine. All of those with a positive response had active or inactive retinal lesions. Some posterior uveitis patients responded to crude retinal extracts but not to S-antigen, indicating the possible role of other retinal antigens still to be purified. Control subjects did not manifest a positive immune response to the S-antigen, nor did patients with anterior uveitis. Possibly, these responses play some role in the pathogenesis of the disease.

MeSH terms

  • Adult
  • Aged
  • Antigen-Antibody Reactions
  • Antigens / immunology*
  • Female
  • Humans
  • Immunity, Cellular*
  • Lymphocyte Activation
  • Male
  • Middle Aged
  • Retina / immunology*
  • Retinal Diseases / immunology
  • Uveitis / immunology*


  • Antigens