Radiorespirometric testing of antibiotic sensitivity in urinary tract infections: concise communication

J Nucl Med. 1980 Feb;21(2):135-8.


A radiometric method, based on inhibition of 14CO2 release from bacterial metabolism of C-14-labeled glucose, was applied to test the susceptibility of urinary organisms to antibiotics. The testing was also carried out by the routine disc diffusion method after isolation of the organisms. Results of susceptibility to antibiotics could be obtained within 2 to 4 hr by the radiometric technique, compared with the 48 hr required for the disc method.

MeSH terms

  • Anti-Infective Agents, Urinary / pharmacology*
  • Bacteria / drug effects
  • Bacteria / metabolism
  • Carbon Dioxide / metabolism
  • Carbon Radioisotopes
  • Glucose / metabolism
  • Humans
  • Microbial Sensitivity Tests / methods*
  • Time Factors
  • Urinary Tract Infections / drug therapy
  • Urinary Tract Infections / microbiology*


  • Anti-Infective Agents, Urinary
  • Carbon Radioisotopes
  • Carbon Dioxide
  • Glucose