Abstract
Rat peritoneal luecocytes incubated with hydrocortisone (10 micrograms/ml) release a factor which inhibits prostaglandin generation. The steroid-induced inhibitor, which mediates the anti-phospholipase effect of antiinflammatory steroids, may be a protein or a polypeptide since its formation is blocked by cycloheximide, a known inhibitor of protein synthesis.
MeSH terms
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Animals
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Arachidonic Acids / metabolism
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Cycloheximide / pharmacology
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Drug Interactions
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Hydrocortisone / pharmacology*
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In Vitro Techniques
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Leukocytes / drug effects
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Leukocytes / metabolism*
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Male
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Prostaglandin Antagonists / blood*
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Prostaglandins / biosynthesis*
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Rats
Substances
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Arachidonic Acids
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Prostaglandin Antagonists
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Prostaglandins
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Cycloheximide
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Hydrocortisone