Formation of apparent presynaptic elements in response to poly-basic compounds

Brain Res. 1980 Feb 17;184(1):85-98. doi: 10.1016/0006-8993(80)90588-0.


Neuronal cell processes in dispersed cell culture grow out onto Sepharose beads coated with poly-basic proteins. Apparent presynaptic elements are formed by these neuronal processes with the bead serving as a postsynaptic element. It is suggested that electrostatic binding between poly-acidic groups on the presynaptic element and poly-basic troups on the postsynaptic element is one of the initial steps in the formation of a synaptic contact in culture.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Adhesion / drug effects
  • Cell Aggregation / drug effects
  • Cell Communication / drug effects*
  • Cells, Cultured
  • Cerebellum / cytology*
  • Hydrogen-Ion Concentration
  • Neurons / drug effects
  • Proteins / pharmacology
  • Rats
  • Synapses / drug effects*


  • Proteins