Epidermotropism in melanoma

J Cutan Pathol. 1980 Feb;7(1):50-4. doi: 10.1111/j.1600-0560.1980.tb00977.x.


Multiple malignant melanocytic lesions developed in a 54-year-old man 4 years after a primary malignant melanoma (Clark level IV) had been excised and 2 months after taking L-Dopa for Parkinsonism. Several of the recurrent lesions that showed junctional melanocytic components were considered primary melanomas and it was suggested that L-Dopa was responsible for malignant transformation of nevi and for rapid progression of the disease. The case was re-examined and on recent evidence it is likely that these lesions were epidermotropic metastases and that L-Dopa played no part in the progress of this unusual tumor.

Publication types

  • Case Reports

MeSH terms

  • Epidermis / pathology
  • Humans
  • Levodopa / adverse effects
  • Male
  • Melanoma / etiology
  • Melanoma / pathology*
  • Melanoma / surgery
  • Middle Aged
  • Neoplasms, Multiple Primary / pathology*
  • Nevus / pathology
  • Skin / pathology
  • Skin Neoplasms / pathology*
  • Time Factors


  • Levodopa