Osteopenia of prematurity: the cause and possible treatment

J Pediatr. 1980 Mar;96(3 Pt 2):528-34. doi: 10.1016/s0022-3476(80)80861-4.

Abstract

By photon absorptiometry, extrauterine bone mineralization in low-birth-weight infants fed a standard commercial formula lags significantly behind intrauterine bone mineralization. In the present study, infants of 28- to 32-week and 33- to 35-week gestational age were studied. The calcium content in a standard formula was increased to provide a daily calcium intake of 220 to 250 mg/kg/day. Phosphate intake was 110 to 125 mg/kg/day. Extrauterine bone mineralization by photon absorptiometry appeared to approximate the intrauterine bone mineralization rate.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bone Diseases / diet therapy*
  • Bone Diseases / etiology
  • Bone Diseases / metabolism
  • Calcification, Physiologic
  • Calcium / metabolism
  • Calcium, Dietary / administration & dosage*
  • Humans
  • Infant Nutritional Physiological Phenomena
  • Infant, Newborn
  • Infant, Premature, Diseases / diet therapy*
  • Infant, Premature, Diseases / etiology
  • Infant, Premature, Diseases / metabolism
  • Phosphorus / administration & dosage
  • Phosphorus / metabolism
  • Vitamin D / administration & dosage
  • Vitamin D / metabolism

Substances

  • Calcium, Dietary
  • Vitamin D
  • Phosphorus
  • Calcium