Patient survival factors in paranasal sinus mucormycosis

Laryngoscope. 1980 Apr;90(4):635-48. doi: 10.1288/00005537-198004000-00010.


Analysis of 170 cases of paranasal sinus mucormycosis collected from the literature and 9 cases of our own revealed a 50% mortality for this disease. When analyzed according to decade, survival has increased to 70% in the cases reported from 1970-1979. There were no significant differences between the survivors and the fatalities when evaluated according to age, sex, laterality, or radiographic findings. There was a markedly poorer prognosis for those patients with hemiplegia, facial necrosis, and nasal deformity. The underlying disease was an important determinant of survival: 75% of patients with no systemic disease, 60% of diabetics, and 20% of patients with other disorders survived. Surgical debridement or radical resection and the use of amphotericin B significantly increased survival. Their combination further enhanced survival, especially in the diabetic.

MeSH terms

  • Adolescent
  • Adult
  • Amphotericin B / therapeutic use
  • Diabetes Complications
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mucormycosis / complications
  • Mucormycosis / diagnostic imaging
  • Mucormycosis / mortality*
  • Mucormycosis / therapy
  • New York City
  • Paranasal Sinus Diseases / complications
  • Paranasal Sinus Diseases / diagnostic imaging
  • Paranasal Sinus Diseases / mortality*
  • Paranasal Sinus Diseases / therapy
  • Paranasal Sinuses / diagnostic imaging
  • Paranasal Sinuses / surgery
  • Prognosis
  • Radiography


  • Amphotericin B