Vertebral osteophyte formation in experimental disc degeneration. Morphologic and proteoglycan changes over time

Arthritis Rheum. 1980 Mar;23(3):319-24. doi: 10.1002/art.1780230309.


Experimental intervertebral disc degeneration produced in rabbits by ventral nuclear herniation reliably produces vertebral osteophytes. Osteophytes arise from proliferating inner annular fibers which undergo metaplasia into cartilage, calcify, and proceed through an endochondral ossification sequence. Proteoglycans extracted from the osteophytes reveal that the degree of aggregation, molecular size of the monomer, and the chondroitin sulfate/keratin sulfate ratio are directly related to the cartilage state of the tissue.

MeSH terms

  • Animals
  • Disease Models, Animal
  • Female
  • Intervertebral Disc / metabolism
  • Intervertebral Disc / pathology*
  • Intervertebral Disc Displacement / complications
  • Intervertebral Disc Displacement / metabolism
  • Intervertebral Disc Displacement / pathology*
  • Proteoglycans / metabolism*
  • Rabbits
  • Spinal Osteophytosis / etiology
  • Spinal Osteophytosis / metabolism
  • Spinal Osteophytosis / pathology*
  • Spine / metabolism
  • Spine / pathology
  • Time Factors


  • Proteoglycans