Obstetric aspects of midtrimester fetal blood sampling by needling or fetoscopy

Br J Obstet Gynaecol. 1980 Feb;87(2):87-99. doi: 10.1111/j.1471-0528.1980.tb04499.x.


We describe our experience at University College Hospital, London, with the first 135 patients submitted to midtrimester fetal blood sampling for antenatal diagnosis of beta-thalassaemia major, other thalassaemias and homozygous sickle cell disease. Blind needling and fetoscopy with sampling are evaluated and their application discussed. With experienced operators 9 per cent of patients experienced a fetal loss.

Publication types

  • Comparative Study

MeSH terms

  • Anemia, Sickle Cell / diagnosis*
  • Blood Specimen Collection / methods
  • Female
  • Fetal Blood / cytology*
  • Fetal Death / etiology
  • Fetal Diseases / diagnosis*
  • Fetoscopy / adverse effects
  • Humans
  • Pregnancy
  • Pregnancy Trimester, Second
  • Prenatal Diagnosis / methods*
  • Thalassemia / diagnosis*