Glomerular epithelial foot processes in normal man and rats. Distribution of true width and its intra- and inter-individual variation

Cell Tissue Res. 1980;205(1):147-55. doi: 10.1007/BF00234450.

Abstract

The width of individual glomerular epithelial foot processes appears very different on electron micrographs. A method for obtainining distributions of the true width of foot processes from that of their apparent width on electron micrographs has been developed based on geometric probability theory pertaining to a specific geometric model. Analyses of foot process width in humans and rats show a remarkable interindividual invariance implying rigid control and therefore great biological significance of foot process width or a derivative thereof. The very low inter-individual variation of the true width, shown in the present paper, makes it possible to demonstrate slight changes in rather small groups of patients or experimental animals.

MeSH terms

  • Adolescent
  • Adult
  • Animals
  • Child
  • Epithelium / ultrastructure
  • Female
  • Humans
  • Kidney Glomerulus / ultrastructure*
  • Male
  • Microscopy, Electron
  • Probability
  • Rats
  • Statistics as Topic