Combination urea and salicyclic acid ointment nail avulsion in nondystrophic nails: a follow-up observation

Cutis. 1980 Apr;25(4):397, 405.


Following the initial report by Farber and South on nonsurgical nail avulsion with urea ointment and their emphasis that the therapy was not helpful in treating nondystrophic nails, we utilized a similar therapy to treat a sixty-seven year old patient who had severe arteriosclerotic cardiovascular disease and relatively nondystrophic but symptomatic large toenail disease. Because their formulation was ineffective on nondystrophic nails, a formulation with an additive, 20 percent urea and 10 percent salicylic acid preparation was used. After a period of two weeks of occlusive paplication, painless nonsurgical avulsion was achieved. Moderate maceration of surrounding skin was temporary and relatively asymptomatic.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Drug Combinations
  • Female
  • Follow-Up Studies
  • Humans
  • Nail Diseases / therapy*
  • Nails / drug effects*
  • Ointments
  • Salicylates / pharmacology
  • Salicylates / therapeutic use*
  • Urea / pharmacology
  • Urea / therapeutic use*


  • Drug Combinations
  • Ointments
  • Salicylates
  • Urea