Mitochondrial calcium overload: A general mechanism for cell-necrosis in muscle diseases

Lancet. 1976 Mar 27;1(7961):672-4. doi: 10.1016/s0140-6736(76)92781-1.


It is suggested that the mechanism of muscle-cell necrosis in various muscle diseases is explained by an increased net influx of calcium into cells which triggers a "vicious cycle" of mitochondrial calcium overloading and energy depletion. If correct, this hypothesis may offer the basis of a more rational treatment of some muscle diseases even before their primary aetiology is known.

MeSH terms

  • Calcium / metabolism*
  • Humans
  • Mitochondria, Muscle / metabolism*
  • Models, Biological
  • Muscles / pathology*
  • Muscular Dystrophies / etiology
  • Muscular Dystrophies / metabolism
  • Muscular Dystrophies / pathology*
  • Necrosis
  • Oxidative Phosphorylation


  • Calcium