Histamine and ascorbic acid in human blood

J Nutr. 1980 Apr;110(4):662-8. doi: 10.1093/jn/110.4.662.


Analysis of 437 human blood samples has shown that when the plasma-reduced ascorbic acid level falls below 1 mg/100 ml, the whole blood histamine level increases exponentially as the ascorbic acid level decreases. When the ascorbic acid level falls below 0.7 mg/100 ml, there is a highly significant increase in the blood histamine level. Oral administration of ascorbic acid (1 g daily for 3 days) to 11 selected volunteers resulted in a reduction of the blood histamine level in every instance.

Publication types

  • Comparative Study

MeSH terms

  • Ascorbic Acid / blood*
  • Female
  • Histamine / blood*
  • Humans
  • Male
  • Pregnancy Trimester, Second
  • Pregnancy Trimester, Third
  • Pregnancy*


  • Histamine
  • Ascorbic Acid