Progressive interstitial lung disease from prolonged methotrexate therapy

Arch Dermatol. 1978 Dec;114(12):1800-2.


Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years. Examination revealed a combined restrictive and obstructive defect in pulmonary mechanics and severe compromise of gas transfer across the pulmonary alveolar-capillary membrane. Improvement in the level of arterial blood gases and pulmonary diffusing capacity occurred after discontinuation of methotrexate therapy. Interstitial fibrosis of the lung is a potential complication of methotrexate therapy for psoriasis.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Humans
  • Lung Diseases / chemically induced*
  • Lung Diseases / diagnostic imaging
  • Male
  • Methotrexate / adverse effects*
  • Methotrexate / therapeutic use
  • Psoriasis / drug therapy
  • Pulmonary Fibrosis / chemically induced
  • Pulmonary Fibrosis / diagnostic imaging
  • Radiography


  • Methotrexate