The significance of multiple detoxification pathways for reactive metabolites in the toxicity of 1,1-dichloroethylene

Toxicol Appl Pharmacol. 1980 Mar 15;52(3):422-32. doi: 10.1016/0041-008x(80)90337-3.
No abstract available

MeSH terms

  • Animals
  • Biotransformation
  • Dichloroethylenes / metabolism*
  • Dichloroethylenes / toxicity
  • Epoxy Compounds / pharmacology*
  • Epoxy Compounds / toxicity
  • Ethers, Cyclic / pharmacology*
  • Glutathione / analysis
  • Glutathione / metabolism
  • Hydrocarbons, Chlorinated / metabolism*
  • Inactivation, Metabolic*
  • Lethal Dose 50
  • Liver / drug effects
  • Male
  • Maleates / pharmacology
  • Maleates / toxicity
  • Mathematics
  • Propylene Glycols / pharmacology
  • Rats
  • Sulfhydryl Compounds / analysis
  • Sulfhydryl Reagents / pharmacology*
  • Time Factors
  • Transaminases / blood

Substances

  • Dichloroethylenes
  • Epoxy Compounds
  • Ethers, Cyclic
  • Hydrocarbons, Chlorinated
  • Maleates
  • Propylene Glycols
  • Sulfhydryl Compounds
  • Sulfhydryl Reagents
  • Transaminases
  • Glutathione