Improvement of medication compliance in uncontrolled hypertension

Lancet. 1976 Jun 12;1(7972):1265-8. doi: 10.1016/s0140-6736(76)91737-2.


38 hypertensive Canadian steelworkers who were neither compliant with medications nor at goal diastolic blood-pressure six months after starting treatment were allocated either to a control group or to an experimental group who were taught how to measure their own blood-pressures, asked to chart their home blood-pressures and pill taking, and taught how to tailor pill taking to their daily habits and rituals; these men were also seen fortnightly by a highschool graduate with no formal health professional training who reinforced the experimental manoeuvres and rewarded improvements in compliance and blood-pressure. Six months later, average compliance had fallen by 1.5% in the control group but rose 21.3% in the experimental group. Blood-pressures fell in 17 of 20 experimental patients (to goal in 6) and in 10 of 18 control patients (to goal in 2).

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Antihypertensive Agents / administration & dosage*
  • Antihypertensive Agents / therapeutic use
  • Blood Pressure
  • Blood Pressure Determination / methods
  • Clinical Trials as Topic
  • Drug Administration Schedule
  • Follow-Up Studies
  • Health Education
  • Home Care Services
  • Humans
  • Hypertension / drug therapy*
  • Male
  • Metallurgy
  • Occupational Diseases / drug therapy*
  • Ontario
  • Patient Compliance*
  • Self-Help Devices


  • Antihypertensive Agents